He dear Elaine, hope to find you well.

After still a year my anxiety and depression is still very present and I am not sure if if is thyroid related.
I had graves 5 years or more ago and got to remission thanks to you.

However , now in perimenopause and due and some stress I am I this situation..
lately my T3 is low... do you think I should be taking medicine and what kind? if so..
This is all I have for now...(From my OBGYN) he has me on hormone replacement.. which I am not sure if will guide me correctly.

Triiodothyronine (T3) 77 L80 - 200 (ng/dL)
Thyroxine (T4) 7.1 4.5 - 11.7 (ug/dL)
F Free thyroxine index (FTI) 7.9 6.0 - 11.0 (ug/dL)
F Free Triiodothyronine(Free T3) 2.49 2.00 - 4.40 (pg/ml)
TSH 1.390 0.400 - 4.500 (uIU/mL)

T3 Uptake 0.9 0.8 - 1.3 (TBI)

Progesterone 0.55 (ng/mL)
Reference Range
Follicular phase 0.057-0.893 ng/mL
Ovulation phase 0.121-12.0 ng/mL
Luteal phase 1.83-23.9 ng/mL

Estradiol 75 (pg/mL)
Adult Female (non-pregnant):
Follicular phase 12.5 - 166
Ovulation phase 85.8 - 498
Luteal phase 43.8 - 211

Follicle-Stimulating Hormone(FSH) 15.0 (mIU/ml)
Reference range
Follicular phase 3.5-12.5 mIU/ml
Ovulation phase 4.7-21.5 mIU/ml
Luteal phase 1.7-7.7 mIU/ml
Postmenopause 25.8-134.8 mIU/ml
Testosterone, Total 108.00 H 4.00 - 50.00 (ng/dL)

He did mention my Estrodiol was high the last time and the cortisol was ok..
Not sure how to check for adrenal function?not sure were to start I have lost a lot of weight
must be due to my anxiety...and depression.

Thank you so much as usual for your help and guidance, and sorry this is so long

Judy

Hi Judy,
I don't see where estradiol is high although testosterone is elevated. For adrenal function we usually test cortisol and ACTH. The T3 uptake is an obsolete test that uses T3 as a reagent to get an idea of how much free T4 you have but today we use the Free T4 test rather than the old calculation. The FT4 index is no longer used except in the case of the very elderly where proteins may be low.
Since high levels of testosterone are seen is adrenal hyperplasia and polycystic ovarian syndrome, these are the conditions your doctor may want to run other tests to either confirm or rule out these causes. If for some reason you've been prescribed testosterone, the dose of replacement hormone would need to be reduced.
You might want to see a functional medicine doctor or a different endocrinologist. Best, Elaine