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Calorie Restriction in Autoimmunity

By Elaine Moore on 10/15/2008

In a recent study, calorie restriction was shown to decrease oxidative stress and increase life span.  Oxidative stress is one of the major causes of autoimmune disease. In previous studies, calorie restriction has been shown to extend life span in experimental animals, and it’s been associated with numerous health benefits in humans.



The study, which was conducted by researchers at the Mount Sinai School of Medicine in New York City and published in the August 2008 issue of the American Journal of Pathology, showed that calorie restriction reduces the number of advanced glycation end products (AGEs), which contribute to aging and oxidative stress.

AGEs are one of the major causes of organ dysfunction, insulin resistance, and decreased longevity. The researchers concluded that the benefits of calorie restriction are likely related to a reduction in oxidative stress rather than decreased energy expenditure.

Autoimmune diseases
calorie restriction
diet

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